Synthetic Peptide for Neuropharmacology Research
Technical Overview
PE-22-28 10mg is a synthetic peptide compound developed for laboratory research involving two-pore-domain potassium channel modulation, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying TREK-1 channel function, synaptic plasticity and mood-circuit signaling, and related biochemical mechanisms.
PE-22-28 is a heptapeptide fragment corresponding to the C-terminal 22-28 region of spadin, the propeptide released during sortilin maturation. It selectively inhibits the TREK-1 (KCNK2) two-pore-domain potassium channel, modulating neuronal excitability in preparations from cortex, hippocampus, and dorsal raphe.
Researchers employ PE-22-28 to probe TREK-1 contributions to fast-onset antidepressant signaling, neurogenesis, and serotonergic activity in rodent brain-slice and primary-culture models. Its relative ease of synthesis compared to full-length spadin makes it the preferred tool compound for TREK-1 antagonism studies.
This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.
Specifications
Compound Name: PE-22-28
Strength: 10mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.
Notice
Provided as a reference material for scientific investigation only.
Purity
≥99% by HPLC · COA available
CAS Number
1234388-01-0
Molecular Formula
C35H55N11O9
Molecular Weight
773.89
Amino Acid Count
7
Sequence
Heptapeptide Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) corresponding to the C-terminal 22-28 region of spadin; linear, unmodified termini (full sequence per COA).
Physical Form
Lyophilized powder
Solubility
Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations.
Storage
Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; store reconstituted material refrigerated and use per laboratory protocol.
