Synthetic Peptide for Metabolic Pathway Research
Technical Overview
Semaglutide is a synthetic peptide compound developed for laboratory research involving incretin signaling and GLP-1 receptor pharmacology, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying receptor-agonist binding profiles, downstream cAMP and insulinotropic signaling responses, and related biochemical mechanisms.
Semaglutide is a long-acting GLP-1 receptor analog featuring an Aib substitution at position 2 to confer DPP-IV resistance and a fatty-acid (C18 diacid) side chain at Lys26 that promotes albumin binding for extended plasma residence. In research models, it is investigated as a tool compound for probing GLP-1R conformational dynamics and beta-arrestin recruitment.
Investigators commonly use this analog to dissect incretin-axis signaling in pancreatic islet preparations, hypothalamic appetite-regulation studies, and gastric motility models. Comparative work alongside native GLP-1 and tirzepatide enables receptor-selectivity and biased-agonism characterization.
This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.
Specifications
Compound Name: Semaglutide
Available Strengths: 5 mg · 10 mg · 20 mg · 30 mg · 50 mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.
Notice
Provided as a reference material for scientific investigation only.
Purity
≥99% by HPLC · COA available
CAS Number
910463-68-2
Molecular Formula
C187H291N45O59
Molecular Weight
4113.58
Amino Acid Count
31
Sequence
31-residue GLP-1 receptor agonist analog with Aib at position 2 and Lys26 conjugated to γGlu-(AEEA)2-C18 diacid; C-terminal carboxylate (full sequence per COA).
Physical Form
Lyophilized powder
Solubility
Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations.
Storage
Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; store reconstituted material refrigerated and use per laboratory protocol.
